In order of number of prescriptions written in 2010, the 10 most-prescribed drugs in the U.S. are:
- Hydrocodone (combined with acetaminophen) -- 131.2 million prescriptions
- Generic Zocor (simvastatin), a cholesterol-lowering statin drug -- 94.1 million prescriptions
- Lisinopril (brand names include Prinivil and Zestril), a blood pressure drug -- 87.4 million prescriptions
- Generic Synthroid (levothyroxine sodium), synthetic thyroid hormone -- 70.5 million prescriptions
- Generic Norvasc (amlodipine besylate), an angina/blood pressure drug -- 57.2 million prescriptions
- Generic Prilosec (omeprazole), an antacid drug -- 53.4 million prescriptions (does not include over-the-counter sales)
- Azithromycin (brand names include Z-Pak and Zithromax), an antibiotic -- 52.6 million prescriptions
- Amoxicillin (various brand names), an antibiotic -- 52.3 million prescriptions
- Generic Glucophage (metformin), a diabetes drug -- 48.3 million prescriptions
- Hydrochlorothiazide (various brand names), a water pill used to lower blood pressure -- 47.8 million prescriptions.
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